Fernblock enhances topical protection + protects skin against damage from pollution
Evaluation & conclusions of the medical study "Evaluation of effectiveness of sunscreen containing Polypodium leucotomos extract in reducing the sun damage to the skin." published in Surgical & Cosmetic Dermatology magazine Reo de Janero and "Fernblock® Upregulates NRF2 Antioxidant Pathway and Protects Keratinocytes from PM2.5-Induced Xenotoxic Stress" published on Hindawi.
Polypodium leucotomos in sunscreen
Erythema was measured according to variations in skin colour (from green to red) (colorimeter): greater variations indicated greater erythema SPF 50+/90 with Fernblock was able to decrease erythema by 6.8% vs SPF 50+/90
Sunburn Cells SPF 50+/90 with Fernblock provided greater DNA protection, reducing formation of sunburn cells.
Preservation of Langerhans Cells The antibody CD1 is a marker used for identifying and quantifying Langerhan cells. SPF 50+/90 with Fernblock provided greater protection of Langerhans cell vs SPF50+/90.
Protection of Skin Architecture
SPF 50+/90 with Fernblock reduced the expression of MMP-1 vs SPF50+/90
SPF 50+/90 with Fernblock reduces pigmentary response vs SPF50+/90
Fernblock activities against damage from pollution
Fernblock® increases Nrf2 expression in cell nucleus
Fernblock® significantly increases Nrf2 expression in normal (healthy) cells (control vs. FB). Upon exposure to PM 2.5, the cells’ natural Nrf2 activity increases (PM 2.5). Upon incubation with Fernblock®, Nfr2 response to PM is greatly increased vs no Fernblock® (PM 2.5 + FB).
Fernblock® increases NQO1 & HO-1 expression in cell nucleus
Fernblock® increases Nrf2 downstream gene expression in normal (healthy) cells (NQO1) and in cells exposed to PM2.5 (NQO1 & HO-1).
Fernblock® increases autophagy
Fernblock® significantly increases autophagy activity in normal (healthy) cells (control vs. FB). Upon exposure to PM 2.5, the cells’ natural autophagy activity increases (PM 2.5). This activity is significantly enhanced when the cells are incubated with Fernblock® (PM 2.5 + FB).